| abstract |
Abstract Compounds of the general formula I wherein R1 signifies hydroxy, lower-alkoxy, amino, mono- or di-lower-alkylamino: R2 signifies hydrogen, alkyl, alkoxy or halogen; R3 , R4 , R5 , R6 , R11 and R12 each independently signify hydrogen or lower-alkyl; R3 and R together signify a methylene or hydroxy-methylene group; R7, R8, R9 and R10 signify hydrogen or lower--alkyl; R11 and R12 together signify an oxo group or spiro--cyclo-lower alkyl; or R11 signifies hydrogen and R12 signifies hydroxy or acetoxy: and one of the residues R13 and R14 signifies hydrogen and the other signifies lower-alkyl or trifluoromethyl, as well as physiologically compatible salts of carboxylic acids of formula I can be used as medicaments, especially for the treatment of neoplasms, acne and psoriasis. The novel compounds can be manufactured by the synthesis of the C(R13)=C(R14) double bond according to Wittig from a corresponding bicyclic component and a corresponding monocyclic component and optional subsequent transform-ation of functional groups. |