| abstract |
PRECISION OF DISCLOSURE: The invention relates to the compounds: (I) in which R1 is an alkyl (C1-C5), R2 is H, alkyl (C1-C5), A is a chain (CH2) n, n being an integer from 0 to 5, or -CH2-O- or an alkylene chain substituted by an alkyl, having in total 2 to 8 carbon atoms, Z is a phenyl optionally substituted by a naphthyl, a indenyl, a heteromonocycle having 5 or 6 members or a heterobicycle, all these radicals possibly being substituted, it being understood that when Z represents a phenyl substituted ortho by an alkoxy, A cannot represent (CH2) n in which n = 0, under all their enantiomeric and diastereoisomeric forms possible and under form of addition salts with acids or salts of quaternary ammonium, their preparation process and the preparation intermediaries. These compounds of formula (I) in particular have a strong affinity for opiate receptors, have analgesic properties central and have antiarrhythmic properties, anti-ischemic cerebral and hypotensive. |