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filingDate 1988-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fbcefa9de21af14c2b6bd15119a4f4a
publicationDate 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-1280755-C
titleOfInvention 6,7-dihydro-5,8- dimethyl-9-fluoro-1-oxo-1h,5h- benzo[ij]quinolizine-2-carboxylic acid and derivatives
abstract ABSTRACT OF THE DISCLOSURE: The compound 6, 7-dihydro-5, 8-dimethyl-9-fluoro-l-oxo-lH,5H-benzo ¦ij¦ quinolizine-2-carboxylic acid, together with its esters, acyl chlorides, alkylaminoalkyl ester salts and pharmaceutically acceptable carboxylate salts are potent antimicrobial agents with a broad spectrum of activity. In a process for producing this compound, four successive intermediates are created then utilised in the eventual synthesis. The five intermediates are: a) 5-carboxyl-6-fluoroquinaldine; b) 1,2-dihydro-6-fluoro-5-hy-droxymethylquinaldine; c) 6-fluoro-5-methyl-1, 2, 3, 4-tetrahydroquinaldine; and d) diethyl 2-[N-(6-fluoro-5-methyl-1,2,3,4-tetrahydroquinaldinyl)] methylenemalonate.
priorityDate 1982-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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