| abstract |
6-(SUBSTITUTED)METHYLENEPENCILLANIC AND 6-(SUBSTITUTED)HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF Abstract Beta-lactamase inhibiting compounds of the formula or (I) (II) or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, arythio, alkyl-thio, alkylsulfonyl or certain heterocyclyl, amino-methyl, thiocarboxamido or amidino groups; one of R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them. |