http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1271751-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e45efeaa6a34dfd9d44fa29a7fe0c806 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 |
| filingDate | 1985-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29656a3bc2ab2a7a1701cb37b7b476c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e546aa81767ce303cc1d030f6b09a66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04cbea4ef026c963659d34678930db09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67485af2bd9ff1c8a61c88c817a23721 |
| publicationDate | 1990-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1271751-A |
| titleOfInvention | Dihydroimidazo[1,2-a]pyrimidine derivatives |
| abstract | Abstract of the Disclosure A dihydroimidazo[1,2-.alpha.]pyrimidine derivative of the formula: wherein R is hydrogen, C1-5 alkyl, heteroaryl, 2,1,3-benz-oxadiazolyl or phenyl which may be substituted by a substi-tuent selected from halogen, C1-4 alkyl, trifluoromethyl, C1-4 alkoxy, nitro and cyano; R1 is cyano, C1-4 alkoxy-carbonyl or -COOCH(R5)CH2R6 [wherein R5 is hydrogen or aryl and R6 is C1-4 alkoxy or -N(Ra)(Rb) (wherein each of Ra and Rb is C1-4 alkyl or aralkyl, or Ra and Rb together with the adjacent nitrogen atom form a heterocycle)]; R2 is C1-4 alkyl, hydroxymethyl, acetoxymethyl, di-C1-4 alkoxy-methyl, C1-4 alkyl-carbamoyloxymethyl or hydroxyimino-methyl; R3 is C1-4 alkyl, formyl, carboxyl, nitro, -N(R7)(R8) (wherein each of R7 and R8 is hydrogen, C1-8 alkyl, aryl, aralkyl or acyl, or R7 and R8 together with the adjacent nitrogen atom form a heterocycle), -OR9 or -SR10 (wherein each of R9 and R10 is hydrogen, C1-8 alkyl, aralkyl or acyl); R4 is hydrogen or -(CH2)mN(Rc)(Rd) (wherein each of Rc and Rd is C1-4 alkyl or aralkyl, or Rc and Rd together with the adjacent nitrogen atom form a heterocycle and m is 1 to 3; n is 0 or 1 to 3 inclusive or an optical isomer thereof, a diastereomer thereof and compounds selected from the group consisting of pharma-ceutically acceptable acid addition salt forms thereof, hydrate forms thereof and mixtures thereof, methods of preparing said compounds and pharmaceutical compositions containing said compounds are disclosed. The dihydroimidazo[1,2-a]pyrimidine derivatives are useful as drugs for the treatment of coronary and cerebral circulatory diseases. |
| priorityDate | 1984-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 149.