http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1268768-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 1987-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14353b703f6b22b36bd30802d57a0760 |
| publicationDate | 1990-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1268768-A |
| titleOfInvention | Trans-6-¬2-(3- or 4-carboxamido-substituted pyrrol- 1-yl)alkyl|-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| abstract | Abstract Certain trans-6-[2-(3- or 4-carboxamido-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical composi-tions are also disclosed. The compounds have the general formula: wherein R1 to R4 and X are as defined in the disclosure and claims. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE40667-E |
| priorityDate | 1986-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.