| abstract |
A B S T R A C T Compounds of the formula (I) :- (I) and their salts are histamine H2-antagonists, wherein : R° is 2-guanidinothiazol-4-yl or a group R1R2N(CH2)nZ- wherein R and R are hydrogen or various substituted alkyl groups or are joined together to form a ring; n is 1 to 6; Z is 2,5-furanyl, 2,5-thienyl, 2,4-pyridyl (wherein R1R2N(CH2)n-is at position 4), 2,4-thiazolyl (wherein R1R2N(CH2)n-is at position 2) or 1,3- or 1,4- phenylene; m is zero or one; Y is a bond, oxygen, sulphur or methylene; p is 2 to 4; q is zero or one; R3 is hydrogen or C1-6alkyl; and R4 is hydrogen or C1-6alkanoyl. Pharmaceutical compositions containing them are described as are processes for their preparation and intermediates therefor. |