| abstract |
TITLE OF THE INVENTION COVALENTLY-MODIFIED NEUTRAL BACTERIAL POLY-SACCHARIDES, STABLE COVALENT CONJUGATES OF SUCH POLYSACCHARIDES AND IMMUNOGENIC PROTEINS, AND METHODS OF PREPARING SUCH POLYSACCHARIDES AND CONJUGATES ABSTRACT OF THE DISCLOSURE Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides and conjugates. |