| abstract |
Abstract 2-Substituted 4-Amino-6,7-Dimethoxyquinolines Novel derivatives of 4-amino-6,7-dimethoxyquinoline are disclosed as regulators of the cardiovascular system, in particular as antihypertensive agents, which have the formula: where R is a dialkylamino, piperidino or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl group, or a piperazino group optionally substituted in the 4-position by an alkyl, aryl, aromatic heterocyclyl, acyl, N-substituted carbamoyl or esterified carboxyl group. Preparation of such compounds by cyclisation of N-(1R-substituted-ethylidene)-2-cyano-4,5-dimethoxy-anilines, and by appropriate treatment of the compound in which R is an unsubstituted piperazino group, is described. |