| abstract |
PRECISION OF DISCLOSURE: The invention relates to a medicinal composition. teuse characterized by the fact that it comprises in an ex-pharmaceutically acceptable container, at least one set of formula (II): (II) as well as its isomers and its pharmaceutically acceptable salts tables, in which a, b and c = 0 or 1, R1, R2, R3, R4, R5 and R6 = H or C1-C6 alkyl, R7 = -CN, oxazolinyl, -CH2OR8 where R8 = H, C1-C6 alkyl, mono or polyhydroxyalkyl C2-C6, cyclopentyl or cyclohexyl, -CH2 -tetrahydropyrranyl, or -CO-R9 where R9 = H, C1 - C6 alkyl, -NR'R "where either R 'and R" = H, C1-C6 alkyl, C3-C6 alkenyl, cyclopentyl, cyclohexyl, aralkyl or aryl, either R 'and R "form a heterocycle with the nitrogen atom to which they are attached, the radical -NR'R " may also represent the remainder of an amino acid or glucosamine, or a radical of formula -OR10 where R10 = H, C1-C18 alkyl or mono or polyhydroxyalkyl C2-C6. These components are particularly useful for the treatment of ailments related to a keratinization disorder (differentiation-proliferation), as well as in treatment inflammatory dermatological conditions and / or immuno-allergic. |