| abstract |
ABSTRACT OF THE DISCLOSURE Certain aminoethyl substituted 1,3-benzthiazol and 1,3-benzoxazol-2(3H) ones having the following formula: in which: X is -S- or -O-; R1 and R2 are, each, hydrogen, C1-6-alkyl, allyl, benzyl, phenethyl, methoxyphenethyl or hydroxyphenethyl; and R3 and R4 are, each, hydrogen, hydroxy, halo, C1-3-alkyl or C1-3-alkoxy, or a pharmaceutically, acceptable, acid addition salt thereof are prepared either by reacting an appropriate o - aminophenol or thiophenol with phosgene or by similar chemical reactions. These compounds have potent dopaminergic activity which is of use for treating hypertension and angina. |