| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
1985-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1988-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ab6d537a38ade643d846ffc85889096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e69a0161b338afafdc80628559166e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ea98e30d513352144bd2d10fc2b1f50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9562d60dc91af4d4c1db74fc50de0e14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c2feeee4dc0a4c99e73b0f6807a6da8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86ce397d1dda6a9d7ba500457cee5d4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee366ffeeefadf2a914d036d442c5205 |
| publicationDate |
1988-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-1241325-A |
| titleOfInvention |
8-alkylthio-2-piperazino-pyrimido[5,4- d]pyrimidines, their preparation and pharmaceutical compositions containing these compounds |
| abstract |
Abstract The invention relates to compounds of general formula I (I) [wherein R1 represents an alkyl group containing 1 to 3 carbon atoms; and R2 represents a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms optionally substituted (except at the carbon atom) by a hydroxy group, or represents a cycloalkyl group containing 5 to 7 carbon atoms or an allyl, phenyl or benzyl group, and R3 represents an allyl yroup or an alkyl group containing 1 to 6 carbon atoms optionally substituted (except at the carbon atom) by a hydroxy group, or represents a cycloalkyl group containing 5 to 7 carbon atoms, or R2 and R3 together with the nitrogen atom between them represent a straight-chained alkyleneimino group containing 2 to 8 carbon atoms] and acid addition salts thereof which have interesting pharma-cological properties, particularly a metastasis-inhibiting effect based on their selective tumour-PDE inhibiting activity, and to pharmaceutical compositions containing these compounds or the physiologically acceptable acid addition salts thereof. |
| priorityDate |
1984-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |