| abstract |
ABSTRACT OF THE DISCLOSURE: Novel aroyl-substituted benzofuran and benzothiophene acetic and proprionic acids are disclosed herein having the formula (I) or a pharmaceutically acceptable salt thereof, and the individual (1) and (d) isomers of the propionic acid or propionate compounds, wherein R1 is hydrogen, hydroxy, lower alkoxy or methyl; R2 is hydrogen or methyl; R3 is hydrogen, alkyl, phenyl, phenyl lower alkyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, wherein the R groups are the same and are lower alkyl; X1 is oxygen or is sulfur if R1 is hydrogen; X2 is oxygen or sulfur; Ar is phenyl unsubstituted or independently substituted with one or more substituents which are lower alkyl, lower alkoxy, halo, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylthio, 2-furyl, 3-furyl, 2-thienyl, or 3-thienyl; and the dotted line represents a single or double bond. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents. |