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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80
filingDate 1985-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1988-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a0b46575b10d1afc1e6ad9eb59f0d7f
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publicationDate 1988-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-1239362-A
titleOfInvention Method for the production of 6-hydroxynicotinic acid
abstract ABSTRACT OF THE INVENTION A process is disclosed for the production of 6-hydroxynicotinic acid by biotechnological methods. Nicotinic acid is enzymatically hydroxylated in the presence of an equivalent quantity of magnesium or barium ions with the help of a nicotinic acid-hydroxylating microorganism. The resultant magnesium or barium salt of the 6-hydroxy-nicotinic acid is separated from the reaction mixture. Then the 6-hydroxynicotinic acid is freed from the separated salts. Examples of the microorganism are those of the genus Pseudomonas, Bacillus or Achromobacter, for example, Achromobacter xylosoxydans. Preferably the enzymatic hydroxylation is carried out at 20° to 40°C. and a pH of 5.5 to 9.0 under aerobic conditions.
priorityDate 1984-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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