| abstract |
ABSTRACT OF THE DISCLOSURE: The invention relates to N-substituted 2-chloro-7-fluoro 10-piperazino-10,11-dihydrodibenzo/b,f/thiepins of the general formula I ( I ) in which R represents an aminocarbonyl, amino-oximinomethyl, 1,3-dioxolan-2-yl or 1,3 dioxan-2-yl group, and their pharma-ceutically acceptable addition salts with organic and inor-ganic acids. These compounds are highly potent anti-dopaminergic, non-cataleptic neuroleptics of presumed use in the treatment of schizophrenia; according to recent pharmaco-logical assay results, the subject compounds are expected to be substantially free of the usual undesired extrapyramidal side effects. The invention also relates to a process for the preparation of these compounds. |