| abstract |
ABSTRACT OF THE DISCLOSURE S(-)-3-[3-acetyl-4-(3-tert.butylamino-2-hydroxypropoxy)-phenyl]- 1,1-diethylureaand its pharmaceutically tolerated acid addition salts, which possess not only astronger .beta.1-receptor blocking action than the racemate but also a pronounced bronchodilating activity. These compounds can be prepared either by racemat resolution by using an enantiomer of di-0,0'-p-toluoyl-tartaric acid or of di-0,0'-benzoyl-tartaric acid as cleavage acid and fractionated crystallization of the diastereomer salts obtained but also by reacting S(+)-3-[3-acetyl-4-(2,3-epoxy-propoxy)-phenyl]-1,1-diethyl-urea with tert.butylamine. O.Z.759 |