| abstract |
ABSTRACT Novel compounds of the formula I wherein B represents a methylene, ethylene or vinylene group, R1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono--alkylamino-alkyl, dialkylamino--alkyl, acylamino-alkyl, phthali-mido-alkyl, alkoxycarbonylamino--alkyl, aryloxycarbonylamino-alkyl, aralkoxycarbonylamino-alkyl, alkyl-aminocarbonylamino-alkyl, arylamino-carbonylamino-alkyl, aralkylamino-carbonylamino-alkyl, alkylsulphonyl-amine-alkyl or arylsulphonylamino--alkyl group, R2 represents a car-boxyl, alkoxycarbonyl or aralkoxy-carbonyl group or a group of the formula (i) or (ii) , R3 represents a carboxyl, alkoxy-carbonyl or aralkoxycarbonyl group, R4 and R5 each represent a hydrogen atom or R4 and R5 together represent an oxo group, R6 and R each re-present a hydrogen atom or an alkyl or aralkyl group or R6 and R7 to-gether with the nitrogen atom to which they are attached represent a 5-membered or 6-membered hetero-monocyclic ring which may contain a further nitrogen atom or an oxygen or sulphur atom, and n stands for zero, 1 or 2, and pharmaceutically acceptable salts thereof have anti-hypertensive activity and can be used as medicaments in the form of pharmaceutical preparations. |