http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1228588-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 |
| filingDate | 1985-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d8d813867d5174f97f046e5aa9d59f7 |
| publicationDate | 1987-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1228588-A |
| titleOfInvention | Intermediates for producing 9-substituted carbacyclin analogs |
| abstract | ABSTRACT Intermediates for preparing 9-substituted carbacyclin analogs of general formula: (Va) or (IXa/Xa) wherein s is one or 2; D is cis-?=C(R3)-, trans-?=C(R3) or ; wherein R3 is H or F; R21 is a silyl-protected group of general formula Si(G1)3, wherein G1 is a conventional silyl-protecting group; R50 is Cl, I, -CF3 or -COOH; Y is cis-CH=CH-, trans-CH=CH-, -CH2CH2- or -C?C-; Z is (i) trans-CH2-CH=CH-, (ii) -CH2-(CH2)f-C(R4)2-, wherein f is zero, one, 2 or 3 and each R4 is the same and is a group selected from H and F, or (iii) when R3 is H, -(Ph)-(CH2)g-, wherein g is zero, one, 2 or 3 and Pn is 1,2-, 1,3- or 1,4-phenylene; Lx is H:H,.alpha.-OR?2:.beta.-H, .alpha.-H:.beta.-OR?2, .alpha.-CH2OR?2:.beta.-H or .alpha.-H:.beta.-CH2OR?2, wherein R?2 is an -OH-protecting group; Mx is .alpha.-OR?2:.beta.-R14 or .alpha.-R14:.beta.-OR?2, wherein R?2 is as defined above and R14 is H or -CH3; L1 is .alpha.-R15:.beta.-R16, .alpha.-R16:.beta.-R15 or a mixture thereof, wherein R15 and R16, independently are H, F or -CH3, with the proviso that one of R15 and R16 is F only when the other is not -CH3; and R17 is (iv) cis-CH=CHCH2CH3, -(CH2)2CH(OH)CH3, -(CH2)3CH=C(CH3)2, , phenyl, benzyl, phenylethyl, phenylpropyl, and , (v) -CmH2mCH3, wherein m is an integer of from one to 5, or (vi) mono-, di- and tri-F, -C1, -CF3, -C1-3alkyl and -C1-3alkoxy-( ring )-substituted-phenyl, -benzyl, -phenylethyl or -phenylpropyl, with the proviso that not more than two substituents are other than C1-3alkyl; or , when taken together, is (vii) , 3-thienyloxymethyl, C4-7cycloalkyl or mono-di- and tri-C1-5alkyl-substituted C4-7cycloalkyl, (viii) -C?CCqH2qCH3, wherein q is an integer of from 2 to 6, or (ix) -CpH2 CH=CH2, wherein p is an integer of from 3 to 7. |
| priorityDate | 1982-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 392.