| abstract |
ABSTRACT OF THE DISCLOSURE New 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and their process of preparation are provided of formula (I) (I) and tautomers thereof, wherein R1 is amino, lower alkylamino, a protected amino, a protected lower alkylamino, hydroxy or lower alkoxy, R2 is hydrogen, acyloxy, pyridinium or a hetero-cyclic-thio group which may have suitable substituent(s), R3 is carboxy or its derivative, A is carbonyl, hydroxy(lower) alkylene or a protected hydroxy(lower)alkylene and R4 is hydro-gen or halogen, or R2 and R3 are linked together to represent a group of the formula: -COO-, wherein R3 is -COO- when R2 is pyridinium, provided that R2 is not acetoxy or 1-methyl-1H-te-trazol-5-ylthio when the group of the formula: is 2-hydroxy-2-(2-amino-1,3-thiazol-4-yl)acetyl or 2-hydroxy-2-[2-(2,2,2-trichloroethoxy)carbonylamino-1,3-thiazol-4-yl] acetyl, as well as pharmaceutically acceptable salts, the new compounds have an antimicrobial activity and are active against a number of pathogenic microorganisms. |