| abstract |
ABSTRACT OF THE DISCLOSURE Derivatives of thiophene-2-carboxylic acid and the pharmaceutically acceptable acid or base addition salts there-of. The compounds of the invention have the structural formula (I), in which R is position 3 or 4 of the thiophene nucleus is hydro-gen, methyl, chlorine or bromine and R1 is hydrogen or C1-C4-alkyl. The compounds have a strong inhibitory effect on the thromboxane synthetase and are useful for the treatment of con-ditions such as inflammation, hypertension, thrombus, apoplexy, asthma, angina pectoris, ischemic heart diseases, ischemic con-ditions, migraine and vascular complications in connection with diabetes. |