| abstract |
ABSTRACT OF THE DISCLOSURE Compounds of general formula I (I) or its lactam tautomer typically, A represents a phenyl, p-hydroxyphenyl, or 2- or 3-thienyl group, R represents a cyclopropyl group, or a group of general formula -NH-R1, [wherein R1 represents a hydrocarbon group; a cycloalkyl group or a 3-pyridyl, 2-furylmethyl, 2-thienylmethyl, 3-imidazolyl-methyl, 2-thiazolylmethyl or 3-pyridylmethyl group; or a group of general formula wherein n is 0 or 1, and R2 and R3, which may be the same or different each represents a hydrogen atom or aminosulphonyl, or a substituted aminosulphonyl and salts thereof with bases. These compounds possess valuable pharmacological properties, in particular an antibacterial activity effective against gram-positive and gram-negative bacteria such as, for example .beta.-lactamase-carrying Escherichia coli and Klebsiella pneumoniae. |