http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1204740-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 |
| filingDate | 1984-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72fb1b46dfd55209e99e99b8c78ae889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_852dfd0acf753f0bc2c22c4226ee7686 |
| publicationDate | 1986-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1204740-A |
| titleOfInvention | Preparation of azinomethyl-rifamycins |
| abstract | ABSTRACT OF THE DISCLOSURE Azinomethyl-rifamycins I (I) wherein Y=H or COCH3 and either R1=C1-C7 alkyl or C3-C4 alkenyl and R2=C1-C7 alkyl, C2-C4 cloro-, hydroxy-, or alkoxy-alkyl C3-C4 alkenyl, cycloalkyl having a C3-C7 ring, cycloalkyl-alkyl having a C3-C6 ring, phenyl or C7-C8 aralkyl optionally monohalogen substituted in the aryl group or NR1R2= a cyclic moiety, said moiety being pyrrolidinyl, piperidinyl, hexahydroazepinyl or heptahydroazocinyl, each of which are unsubstiiuted or substituted with 1 or 2 methyl radicals, 4-alkyl-1-piperazinyl, morpholinyl or 1,2,3,4-tetrahydroisoquinolinyl are prepared from rifamycin S by (a) dissolving the rifamycin S in tetrahydrofuran, CHC13, dioxan, CH2C12 or dichloroethane (b) adding (i) a Schiff's base CH2=NR3 wherein R3= t-alkyl or (ii) a compound R4N(CH2OR5)2 wherein R4=lower alkyl, lower alkenyl, cycloalkyl having a C5-C6 ring, phenyl, benzyl or .alpha.- or .beta.-phenethyl and R5=H or lower alkyl or (iii) a compound Abstract continued.... wherein R6=C1-C6 alkyl, cycloalkyl having a C5-C6 ring or alkenyl (c) adding hydrazine and (d) adding a chloroformiminium chloride wherein R1 and R2 are as above defined. |
| priorityDate | 1983-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.