abstract |
Abstract of the Disclosure 7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.-pregna-1,4-diene-21,17-carbolactones of the formula wherein the 15,16-methylene group can be in the .alpha.-or .beta.-configuration, and R is a lower alkyl residue, have altialdosterone activity. They are prepared from corresponding .DELTA.4-unsaturated compounds by chemical or microbiological 1,2-dehydrogenation. |