http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1201117-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5e07888f923b7443f3b8eb913614893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-04 |
| filingDate | 1982-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5cda429a8fb2c97847bc38acfff70f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4218c338df8d22e76ba7fe34603f3873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e17ef1938c839a0f1fde12cf133539d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3375ca0137adcf8e3aa6a676c07368d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c55db3854c2e009d04662f8f973bdeac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5f265feec50690adabfc532389d974d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c711a0db982b93cab0d6cbd59dfa902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23306636dd6f19c2b2ca394aedef84e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04a4680645e8593c9981c12273b9fe26 |
| publicationDate | 1986-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1201117-A |
| titleOfInvention | NOVEL AMINOACRIDINE-.alpha.- AND/OR -.beta.-(D)-N-GLYCOSIDE AND AMINOACRIDINE-.alpha.- AND/OR -.beta.-(L)-N-GLYCOSIDE DERIVATIVES |
| abstract | Abstract The invention relates to novel aminoacridine-d, .beta.-(D)- and -(L)-N-glycoside derivatives, the salts thereof and to a novel process for the pre-paration of such compounds. The novel compounds have the general formula I I wherein n is 0 or 1 P is 1, 2 or 3 A is an anion preferably a halogen ion R is hydrogen, dimethylamino or a group of the general formula II II wherein R1 is hydrogen or a methyl group and R2 is hydrogen or a sugar residue, and the two substituents X are identical or different and stand for hydrogen, a group of the general formula II or for halogen, a C1-4 alkyl group, a C1-4 alkoxy group, for a nitro-, cyano-, carbomethoxy-, carbamoyl-, phenyl- or a C1-4 alkylphenyl group, with the restriction that at least one of the substituents R, X and X represents a group of formula II with R2 = sugar residue, and R3 is hydrogen or a C1-5 alkyl group. According to the invention the compounds are prepared by reacting compounds of the general formula III III wherein n is 0 or 1 P is 1, 2 or 3 A is an anion preferably a halogen ion Z is an amino-, methylamino- or dimethylamino group or hydrogen, R3 is as dafined above and the two substituents Y are identical or different and stand for hydrogen, an amino-, methylamino- or dimethylamino group or for halogen, a C1-4 alkyl- or alkoxy group, for a nitro-, cyano-, carbomethoxy-, carbamoyl-, phenyl- or (C1-4 alkyl) phenyl group, with the restriction that at least one of the substituents Z, Y and Y repre-sents a free or monosubstituted amino group, or the acid addition salts there-of in a polar solvent containing water with the corresponding sugars. The glycosides of the general formula I exert a strong tumour inhibiting effect. Their toxicity is lower than that of starting compounds having no sugar group. |
| priorityDate | 1982-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 147.