http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1198697-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3511804597328d71b869065cfb6950ce |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6402 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate | 1983-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1985-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a031ea2ffdffe0030bd5359725cb5c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85328f0929743320f1adba151d45d807 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7343339c9814a507c1916539cc5a947 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21a5967e21dd57880f9e932a03bc9e0a |
| publicationDate | 1985-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1198697-A |
| titleOfInvention | Thrombolytic agent |
| abstract | ABSTRACT OF THE DISCLOSURE The invention discloses that the tissues of earth-worms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification proce-dures into the individual active ingredients including six novel proteases named F-O-HM-45, F-I-l-HM-54, F-I-2-HM-15, F-II-HM-64, F-III-l-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014036655-A1 |
| priorityDate | 1982-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 266.