http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1198420-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-14 |
| filingDate | 1982-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1985-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d20de3e1bbf91064ec5a063700dd1d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea6a4ee48aeff0b3ec741a5055befd68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb892cd4315824d852c1faa1e380fe56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eb17673d014ba82ff29ac02d6f6e00c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_511145895fa97c857403ebad2dc0bc79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78363c45033d022ea4827fb32d73e7c3 |
| publicationDate | 1985-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1198420-A |
| titleOfInvention | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| abstract | ABSTRACT The invention relates to new compounds of formula I I wherein R is (a) a free or esterified carboxy group; (b) -C(OR')3, where each R' group is independently Cl-C6-alkyl or phenyl; (c) -CH2-R", where R" is hydroxy or C2-C7-alkoxy; (d) , where Ra and Rb are chosen inde-pendently from the group hydrogen, Cl-C6-alkyl, C2-C6-alkanoyl and phenyl; (e) -C?N; (f) radical; (g) -CHO; or (h) radical where each X' is independently -O- or -S- and the R'a and R'b groups, whether the same or different, are Cl-C6-alkyl or together form a straight or branched C2-C6-alkenylene chain; D is: (trans), -C?C-, ?C=O, -O-, -S-, or ?N-Rc, where Rc may be hydro-gen, Cl-C6-alkyl or C2-C6-alkanoyl; one of R1 and R2 and, independently, one of R3 and R4 is hydrogen, Cl-C6-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, phenyl, or aryl-Cl-C6-alkyl and the other is hydrogen, hydroxy, Cl-C6-alkoxy or aryl-Cl-C6-alkoxy, or, R1 and R2 and, independently, R3 and R4 together form an oxo group; each R5 and R6, whether the same or different, may be hydrogen, Cl-C6-alkyl or halogen, or R5, R6 and the carbon atom to which they are bound form a ?C=CH2 or radical; Y is: -C?C-, (trans), (cis) where Z is halogen, -NH-CO- or -NH-CH2-; X is: -(CH2)m3-in which m3 is zero or 1, (cis), (trans), -O-, -S-, or ?N-Rc where Rc is as defined above; m1, m2, n1 and n2, whether the same or different, may be zero or an integer between 0 and 12 such that each m1 + m2 and n1 + n2 is less than or equal to 15; p and q are independently zero or an integer between 1 and 3 such that the sum p + q is an integer of 1 to 6; R7 is a cycloaliphatic radical, either unsubstituted or substituted with one or more Cl-C6-alkyl or Cl-C6-alkoxy; or a saturated or unsaturated heterocyclic ring, either unsubstituted or substituted with one or more of the following: halogen, halo-Cl-C6-alkyl, Cl-C6-alkoxy, phenyl, Cl-C6-alkyl; and the lactones derived from compounds of formula I and the pharmaceutically or veterinarily acceptable salts thereof. The compounds display broncho-dilator, luteolytic, anti-ulcerogenic and platelet anti-aggregant activity. |
| priorityDate | 1978-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 292.