http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1181080-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d48d1bb63c8f7c7e3ddba047bce73fca |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1984-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1985-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85b9881ee9284d61b1bb1f9a9ef35af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccb498b3cb98f1501873afded0701831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c871bc0877b1f24c25c4a2c988859de4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52902d61c57cf90c6d78f208fa01fc9b |
| publicationDate | 1985-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1181080-A |
| titleOfInvention | Imidazolylphenyl amidines, processes for their preparation and their pharmaceutical use, and intermediates of preparation |
| abstract | ABSTRACT OF THE DISCLOSURE The invention relates to a process for preparing a compound of formula IX (IX) in which R and R1, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, and B represents a cyano, acetyl, carbethoxy or carbamyl group, or an acid addition salt thereof, which process comprises reacting an amine of formula II (II) (wherein R is as defined above) with a compound of formula X (X) wherein R1 and B are as defined above, or in the case where B represents a cyano group, reacting an amine of formula II with cyanamide in the presence of a compound of formula VII (VII) where R1 is as defined above and Y is a lower alkyl group and, where required, forming an acid addition salt thereof. The invention further relates to compounds of formula (IX) as defined above or acid addition salts thereof. Compounds of formula (IX) are useful as intermediates in the preparation of pharmacologically active substituted imidazolylphenyl amidines which are H2 receptor blocking agents inhibiting gastric acid secretion (as antiulcer agents). |
| priorityDate | 1980-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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