| abstract |
D.P.C. (Ph) 6379 SPARINGLY WATER-SOLUBLE SALTS OF PENICILLANIC ACID 1,1-DIOXIDE Abstract The 1:2 N,N'-dibenzylethylenediamine, the N-benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known beta-lactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals. |