http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1175429-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 |
| filingDate | 1982-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc50ea0b690e745243c0055850513558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d92ee527dc5cfff1bc9197f6964c15f |
| publicationDate | 1984-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1175429-A |
| titleOfInvention | 1-substituted-3-(substituted - amino)-5-(pyridinyl)- 1h-pyrazolo[3,4-b]pyridines, their preparation and use as cardiotonics |
| abstract | ABSTRACT OF THE DISCLOSURE l-R-3-(NB)-5-PY-6-Q-1H-pyrazolo[3,4-b]pyridilles or pharmaceuti-cally-acceptable acid-addition salts thereof which are useful as cardiotonics, are prepared by reacting a l-R-5-PY-6-Q-1H-pyrazolo[3,4-b] pyridin-3-amine with a lower-alkanoic acid and reducing agent to produce 1-R-3-(NB)-5-PY-6-Q-1H-l-pyrazolo[3,4-b]pyridine (I) where NB is NHR1 or NRlR2, with a mixture of formic acid and formaldehyde to produce I where NB is N(CH3)2 or with a lower-acylating agent to produce I where NB is NHAc and, if desired, reacting the 3-(NHAc) compound with a reducing agent to prepare the corresponding 3-NHR1 compound, where R is lower-alkyl, lower-hydroxyalkyl, lower-acyloxy-(lower-alkyl) or lower-alkoxy-alkyl, Q is hydrogen or lower-alkyl, PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, and NB is selected from NHR, NR1R2 or NHAc whcre R1 and R2 are each lower-alkyl and Ac is lower-acyl. Also shown are cardiotollic compositions and method for increasing cardiac con-tractility using said compounds or salts. |
| priorityDate | 1981-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 339.