| abstract |
Abstract There are presented pyrimido[4,5-d][2]benzazepines of the formula wherein R1 is hydrogen, lower alkyl, chloro, bromo, lower alkoxy, hydroxy, lower alkylthio or NR4R5 wherein R4 and R5 are hydrogen, lower alkyl or di-lower alkyl-amino lower alkyl; R2 is hydrogen, lower alkyl or amino; R3 is hydrogen, acyloxy or hydroxy; X is halogen having an atomic number not greater than 35 and Y is hydrogen or halogen having an atomic number not greater than 35 and the 6-oxides thereof when R3 is hydrogen and the pharmaceutically acceptable salts thereof. These pyrimido[4,5-d][2]benzazepines are useful as anxiolytic and sedative agents. Also presented are processes and intermediates in the production of the abovepyrimido[4,5-d][2]benzazepines. |