http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1159055-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 |
| filingDate | 1981-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccbfff221e0c34f4597ba9ac8ef95c2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42dc5d3b4e1a7bfed1385fe248b463af |
| publicationDate | 1983-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1159055-A |
| titleOfInvention | Use of vlb 3-(2-chloroethyl) carboxamide in treating neoplasms |
| abstract | Abstract A pharmaceutical formulation which comprises as an active ingredient (VLB or 4-desacetyl VLB) 3-(2-chloroethyl) carboxamide or a pharmaceutically-acceptable acid-addition salt thereof with a pharmaceutically-acceptable carrier therefor. Processes for preparing the active ingredient include (1) hydrolyzing the corresponding spirooxazolidinedione, (2) reacting the carboxazide with 2-chloroethylamine, and (3) reacting the 3-(2-hydroxyethyl)-carboxamide with a reagent which facilitates the replace-ment of a hydroxy function with chlorine and a source of chlorine. The process may include the optional steps of deacetylating, acetylating; and salifying the free base formed by the first-mentioned process of hydrolysis. |
| priorityDate | 1980-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.