http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1157013-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-16 |
| filingDate | 1983-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f81359cbf93393d32bac58754239518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_135bffe6572a4acc22d407cb4376c1de |
| publicationDate | 1983-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1157013-A |
| titleOfInvention | Process for the preparation of (substituted)-2- carbamoyloxymethylpenam and (substituted)3- carbamoyloxycepham |
| abstract | ABSTRACT Penicillin sulfoxide ester are reacted with an iso-cyanate to produce the corresponding (substituted)-2-carbamoyl-oxymethyloeban, the corresponding (substituted)-3-carbamoyl-oxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively. Novel penams and cephams provided by the present invention (after removal of the carboxyl-protecting group to produce the free acid) are active against various Gram-positive and Gram-negative organisms and, accordingly, are useful antibacterial agents for the treatment of diseases caused by such organisms in animals, including man. |
| priorityDate | 1978-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 295.