| abstract |
ABSTRACT OF THE DISCLOSURE The invention concerns new compounds of the general formula (I) (I) wherein R1 is hydrogen, phenyl or phenyl substituted with one or more alkyl hav-ing 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; R2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, phenyl, or phenyl substituted with one or more alkyl having 1 to 4 carbon atoms, haloyen, alkoxy having 1 to 4 carbon atoms or nitro; R3 is alkoxy having 1 to 4 carbon atoms or hydrogen; R is hydrogen, alkyl having 1 to 4 carbon atom optionally substituted with alkoxy having 1 to 4 carbon atoms, benzyloxy or cyano group, phenyl, or phenyl substituted with one or more alkyl haviny 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro, or a phenyl-(C1-4alkyl)-alkyl group, in which the phenyl moiety may bear an alkoxy substituent having 1 to 4 carbon atoms or a halogen; m and n represent 0, 1 or 2, and acid addition and quaternary salts thereof. The compounds are potent vasodilators and exert a favourcable influence on the extremital blood flow. They also show a heart function influencing activity. Methods for the preparation of said compounds and pharmaceutical oompositions containing them are also subject of the invention. |