abstract |
ABSTRACT OF THE DISCLOSURE Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2-acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding 11-reactive compound with a reactive sulfur compound to form 11-sulfino compounds and, if desired, oxidizing the 11-sulfino compounds to obtain 11-sulfo compound. |