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filingDate 1980-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1983-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-1146885-A
titleOfInvention Antibiotically active compounds and their fermentative preparation
abstract Abstract New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X = : R1 = OH: R2 = H), 3, 31-dihydroxy-rifamycin S (formula A: X = : R1 = R2 = OH) and 1-desoxy-1-oxarifamycin S (formula A: X = -O-: R1 = R2 = H) (A) are formed by sultivating, under aerobic conditions, a strain of Nosardia mediterranei which is derived from Streptomyces ??diterranei ATCC 13 685 as the parent strain and is characterised by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia meditarranei DSM 1415 has proved suitable. The mentioned ?ifamycin S a????gues have analogous anti-biotic properties to this but have a wider range of action, especially against gram-negative bacyeria.
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