| abstract |
ABSTRACT OF THE INVENTION Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: (I) wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalky-loxy, arylhydroxymethylene, arylcarbonyl, arylalkyl-carbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or (ii) A is an -SO2- group and R is aryl or heterocyclyl or (iii) A is a chemical bond and R is a heterocyclyl or substituted phenyl group, or (iv) A is an aliphatic hydrocarbon residue of from 1 to 3 carbon atoms and R is a halophenyl group. Some of these imidazoles and salts are novel. Methods of preparing the imidazoles are disclosed The imidazoles and their salts are useful in the treat-ment or prophylaxis of thrombo-embolic conditions. |