| abstract |
PRECISION OF DISCLOSURE: The invention relates to novel compounds with the general formula (I ') (I ') in which R3 represents an alkyl radical containing 2 with 4 carbon atoms, R'4 represents a hydrogen atom, a hydroxyl radical, or an acyloxy radical containing from 1 to 18 carbon atoms and, or else R1 and R2, identical or different, represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms or an alkenyl or alkynyl radical containing 2 to 6 carbon atoms, it being understood that only one of the substituents R1 and R2 can represent a hydro-gene, or R1 and R2 together form a cycloalkyl radical containing 3 to 8 carbon atoms. Compounds according to the invention are aldosterone antagonists and increase hydrosodium diuresis with conservation of organic potassium. They have no side effects. |