| abstract |
ABSTRACT There are described compounds of formula I, I in which an adjacent pair of R5, R6, R7 and R8 form a chain -CZC(G1)=C(G2)-Z-, R4, R9 and the remainder of R5, R6, R7 and R8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, -NO2, -NH1R2, -OR3, -S(O)nR3; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen, n is 0, 1 or 2, R1 and R2, which may be the same or different, each represent hydrogen, alkyl, -CONHR3, phenyl or phenyl substituted by alkyl or halogen, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring, R3 represents hydrogen, alkyl, alkenyl or phenyl, one of G1 and G2 is hydrogen and the other is a group B, each B, which may be the same or different, is -COOH, a 5-tetrazoly group, or a carboximidoterazole group, each Z, which may be the same or different, is oxygen or sulphur, and one or two of the atoms a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R9 having no significance when two of a, b, c and d are nitrogen, (with certain exclusions) and pharmaceutically acceptable derivatives thereof, There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them, The described compounds of formula I are useful as pharmaceutical, e.g. anti-allergic, agents. |