| abstract |
ABSTRACT Geminal dihalogen derivatives of condensed pyrimidine-4-one compounds of the general formula I [wherein R represents hydrogen, lower alkyl, or lower alkoxycarbony; R1 represents hydrogen, lower alkyl, carboxy, ester group or a derivative thereof, cyano, phenyl or halogen; R2 represents hydrogen, lower alkyl or phenyl; X represents halogen; n is the integer 0, 1 or 2] and the salts and optically active antipodes thereof. The compounds I are valuable intermediates in the synthesis of compounds having antiallergic or antiasthmatic activity and some of the compounds I themselves posses pharmacological activity. |