| abstract |
ABSTRACT N-Benzyl-imidazoles of the formula: ---(I) wherein R1 is hydrogen, C1-C4 lower alkyl, C1-C4 lower alkoxy or halogen, Y is (CH2)n where n is an integer of from 1 to 4, or a group of the formula: , Z is CO2R2, CONHR3, CON(R4)2, CN or tetrazolyl, wherein R2 is hydrogen or C1-C4 lower alkyl, R3 is hydrogen, C1-C4 lower alkyl or C2-C4 lower alkanoyl, each R4 is C1-C4 lower alkyl or two groups R4 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino group, and the pharma-ceutically acceptable acid addition salts thereof and bioprecursors therefor, are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes. |