| abstract |
ABSTRACT OF THE DISCLOSURE 13-Thiaprostanoic acid derivatives of the general Formula I (I) wherein A is -CO- or -CHOH-; B is -CH2CH2- or -CH=CH-; Q is 1,4-phenylene or 1,4-naphthylene; R1 is H or OH; R2 is H or CH3; R3 is alkyl with 1 - 8 carbon atoms or alkyl with 1 - 8 carbon atoms substituted by (a) phenyl, (b) phenyl. substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; (c) phenoxy or (d) phenoxy substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; and R4 is NH2, CH3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino. These compounds are useful for lowering blood pressure as well as for other pharmaceutical purposes. They also are useful inter-mediates for the preparation of other known pharmaceuticals such as the 13-thiaprostaglandins. |