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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24
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filingDate 1978-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1981-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_914f04347ec77a9c59584c48f62324ec
publicationDate 1981-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-1109876-A
titleOfInvention Demethylation of (-)-1-(p-methoxybenzyl)-2-methyl-1,2, 3,4,5,6,7,8-octahydroisoquinoline
abstract ABSTRACT N-Alkyl allylic tertiary amines are dealkylated as illustrated by treatment of (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline in cold methylene chloride with m-chloroperbenzoic acid followed by the addition of aqueous ferrous chloride to provide a good yield of (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline with substantial if not complete retention of optical activity. The product is an inter-mediate in a synthesis of the analgesic known as butor-phanol.
priorityDate 1977-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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