http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1107730-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-04 |
| filingDate | 1978-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b3d40cfaf052d90f3fc628cf0235638 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71770a536ddbc9262e26801d78a4cd2e |
| publicationDate | 1981-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1107730-A |
| titleOfInvention | 2,1-benzisothiazoles and preparation thereof |
| abstract | ABSTRACT OF THE DISCLOSURE Novel 3-(Substituted-amino-2,1-benziso-thiazoles useful as anti-inflammatory agents having the Formula I wherein R1 is hydrogen, metheyl or ethyl; R2 is IA , or -Y-NR4R5; or R1 and R2 taken together with the nitro-gen atom are piperazinyl, N-lower alkylpiperazinyl or N-phenylpipazinyl; R3 is methyl or ethyl; R4 and R5 are hydrogne, lower-alkyl or hydroxy-lower alkyl; or R4 and R5 taken togther with the nitrogen atom are pyrrolidino, piperidino, hexamethyleneimino, piperzinyl, N-lower alkylpiperazinyl or N-phenyl-piperazinyl; Y is an alkylene group containing from 2 to 8 carbon atoms and separating the two nitrogen atoms by at least 2 carbon atoms; X occupies any of positions 4,5,6, or 7 and is selected from the group consisting of methoxy and halo; and n is 1 or 2; or 0, 1 or 2 when R2 is (IA), said compounds are prepared by reductive cyclization of appropriately substituted 2-nitro-thiobenzamides or by reaction of 3-chloro-2,1-benz-isothiazoles with suitably substituted amines. |
| priorityDate | 1978-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 182.