http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1104126-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8cbc6261d883f27c8339ffb4b4cfeaa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 1977-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4df06a12c66da1a1893c4357725048f3 |
| publicationDate | 1981-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1104126-A |
| titleOfInvention | Method for producing derivatives of penicillanic acid |
| abstract | Ry/1t/461 F Abstract of disclosure The present invention relates to a method for the preparation of a compound of the general formula I, II, or III I II III in which -A- stands for a straight or branched, saturated or unsaturated aliphcatic hydrocarbon radical, containing from 1 to 6 carbon atoms, which radical optionally can be substituted with an amino radical; R1 stands for hydrogen, or a lower alkyl radical with from 1 to 4 carbon atoms; R2 stands for hydrogen, a lower allkyl radical with from 1 to 4 carbon atoms, or a monoacyl radical derived from a mono- or dibasic carboxylic acid, sulphuric acid, a sulphonic acid, a sulphinic acid, phosphoric acid, or a phosphonic acid, and R2 can represent an unsubstituted or substituted carbamoyl, guanyl and guanylcarbamoyl radical; R1 and R2 together with the nitrogen atom can form a monocyclic, saturated ring having from 4 to 8 carbon atoms; furthermore R1 and R2 together can represent a radical of the formula , in which R3 and R4 each stands for hydrogen, lower alkyl, phenyl or phenyl-lower alkyl, or in which R3 and R4 together with the nitrogen atom form a mono-cyclic, saturated ring having from 4 to 7 carbon atoms; the groupings: ; ; ; repesent saturated, monocyclic, bicyclic or spirocyclic ring systems, respectively, containing from 4 to 11 carbon atoms in total; P stands for the penicillanic acid radical of the formula IV; IV and salts of the compounds of the formulae I, II, and III with pharmaceutically acceptable, non-toxic organic and inorganic acids or bases, and easily hydrolyzable pharma-ceutically acceptable, non-toxic esters of the penicillanic acid derivatives of formulae I, II, and III, including diesters of the formula V: V in which X and Y can be the same or different and stand for an acyl radical of one of the compounds of formulae I, II, and III, and Y furthermore can be the acyl radical of other known .beta.-lactam antibiotics, R5 stands for hydrogen, methyl, ethyl, or phenyl, and salts of such esters with pharmaceutically acceptable, non-toxic acids or bases. The compounds prepared according to the invention have shown increased activity against a series of bacteria which cause infections difficult to combat with the presently available antibiotics. |
| priorityDate | 1976-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 239.