http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1102790-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a0e90292f2ba83d7878baca3838b8a2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 |
| filingDate | 1977-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00da3be85cb7302d83655d7f63733d23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_626b46544cd1b75cf0b4b4b3dcfcbfb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2c2359b5528210c9d782f81189f2083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392df9cb684a8d9b77b9968d7fa99fd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_109e6bb165433dbda14992b5d4fcd634 |
| publicationDate | 1981-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1102790-A |
| titleOfInvention | 3,7-disubstituted cephalosporins and preparation thereof |
| abstract | ABSTRACT OF THE DISCLOSURE: The present invention relates to a process for preparing new 3,7-disubstituted cephalosporins. More particularly it relates to 7-acylamino-3-pyrazinylthiomethyl-3-cephem-4-carboxylic acids are disclosed having the general formula: (I) wherein R is an alkyl having from 1 to 5 carbon atoms or R2-CH2-, R2-X-(CH2)n-, , and wherein Y=Y1=H Y=Y1=C1 Y=C1, Y1=F Y=H, Y1=C1 and in which n is an integer from 1 to 4, X is O or S, and R2 is thienyl, phenyl, 1,4-cyclohexadienyl, phenoxy, pyrazinyl and substituted phenyl, thienyl, pyrazinyl and phenoxy, the substituent being selected from the group consisting of hydroxy, chlorine, bromine, and alkyl and alkoxy having from 1 to 4 carbon atoms; R3 is alkali metal such as sodium or potassium, hydrogen, alkyl having from 1 to 4 carbon atoms, benzyl, trichloroethyl, methoxybenzyl, benzhydryl, pivaloyloxymethyl, and an alkaline earth metal; R1 may be a pyrazinyl of the general formulae: Abstract continued: or or (II) (III) (IV) in which R4, R5, R6 are equal or different and are selected from the group consisting of F, C1, Br, hydrogen, alkyl, phenyl, cyano, thiocyano, carboxyl, carboxyalkyl, carboxamido, thiocarboxamido, hydroxy, alkoxy, thiol, alkylthio, amino, alkylamino, phenylamino. By the terms alkyl, an alkyl having from 1 to 4 carbon atoms is intended. Processes for making them are also disclosed. The new cephalosporin derivatives of formula (I) exhibit a broad spectrum antibacterial activity and are useful as therapeutic agents in the treatment of infectious diseases caused by gram-negative and gram-positive bacteria. |
| priorityDate | 1976-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.