| abstract |
ABSTRACT OF THE DISCLOSURE Novel compounds are disclosed of the formula: (I) and the pharmaceutically acceptable acid addition salts thereof, wherein: Ar1 and Ar2 are each independently selected from the group consisting of phenyl, substituted phenyl and pyridinyl, wherein said substituted phenyl is phenyl having from 1 to 2 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy trifluoromethyl and nitro; m is an integer zero or 1; A is a member selected from the group consisting of and , provided that when said A is then said m is zero and when said A is then said m is 1; n is an integer of from 2 to 6 inclusive, provided that when CnH2n represents a branched alkylene chain, then at least 2 carbon atoms are present in the linear portion of the chain linking B with the piperidine or piperazine nitrogen atom; and B is a member selected from the group consisting of: a) a radical having the formula wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; and Y is a member selected from the group consisting of oxygen, sulfur and a substituted nitrogen of the formula , wherein said L is a member selected from the group consisting of hydrogen, lower alkyl, lower alkylcarbonyl, lower alkyloxycarbonyl-lower alkyl, carboxy-lower alkyl, phenyl, phenylmethyl, lower alkylaminocarbonyl, hydroxy-methyl, and lower alkenyl; and b) a radical having the formula wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; and M is a member selected from the group consisting of hydrogen, lower alkyl, phenyl, phenylmethyl, mercapto, lower alkylthio, amino, lower alkylcarbonylamino, lower alkyloxycarbonylamino, and cycloalkyl having from 3 to 6 carbon atoms. Theses novel 1-substituted 4-(diarylmethyl)piperazine and 4-(diarylmethoxy) piperidine derivatives having anti-anaphylactic and antihistaminic properties. |