http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1095039-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbba3945f32892565b39a80aaef3481c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 |
| filingDate | 1979-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e869a8631715e984db480eb7061d9c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dc578f30980db99b74d1d71ad7d78ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d06b59b1966a7e0a3ad5423da2fdf4a |
| publicationDate | 1981-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1095039-A |
| titleOfInvention | Process for obtaining novel arylic ethers and products therefrom |
| abstract | PRECISION OF DISCLOSURE The subject of the invention is aryloxy alkyl piperidines of general formula I: in which: R2 is hydrogen or an alkyl radical inferior; R3 is an acyl radical derived from an organic acid alkyl carboxylic having from 1 to 10 atoms of carbon; R4 is a phenyl or phenyl radical substituted by one, two or three halogen, alkyl radicals lower, lower alkoxy or alkylene dioxy inferior; Ar is an aromatic cyclic radical homocyclic or heterocyclic chosen in the group made up of a) a phenyl radical of general formula: in which D is a halogen, a lower alkyl radical, a lower alkenyl radical, an alkenyloxy radical, a radical lower alkynyloxy, a lower alkyl thio radical, a carboxyl, a lower alkoxy carbonyl radical, a radical nitro, amino, (lower alkyl amino), di (lower alkyl) amino, lower amino acyl, sulfamido, lower amino alkyl sulfonyl, di (lower amino alkyl) sulfonyl, alkylsulfonyl lower, amino carbonyl, cyano, trifluoromethyl and alkylene-dioxy and m is an integer varying from 0 to 5 b) a bicyclic radical of general formula: in which: - Z and A together form an ethylidene radical, B and E together form an ethylidene radical and p is equal to 1, - Z is an imino radical - NH -, A and 8 together form a ethylene or ethylidene radical, E is a methylene radical and p is a whole number varying from 0 to 2, - Z is a sulfur atom, A and B together form a ethylene or ethylidene radical, E is a methylene radical and p is an integer varying from 1 to 3. X is a bivalent radical chosen from the group consisting of -CH2 - CH2-,? H - CH2, -CH2 -? H -,? H -? H-, -CH2 - CH2 - CH2-and CH2 - CH2 -? H -in which R represents a lower alkyl radical and n represents an integer equal to 1 or 2 which are obtained by different processes and in particular that which consists in condensing a 4-aminopiperidine of formula general III: III in which the definition of the substituents R2, R3 and R4 remains that previously supplied with an aryloxy ester alkyl of general formula II: Ar - O - (X) n - Y in which Ar, X and n are defined as above and Y is a halogen atom or the acyl radical of an acid alkyl - or aryl sulfonic to obtain a compound of formula general I as we can. if applicable. add salt of a mineral or organic acid or split into its isomers optics or its isomeric diastero using physical methods sic or chemical. The compounds of general formula I as well as their salts, obtained according to the methods of the invention. find a use in therapy, in particular as a drug for hyper-voltage. |
| priorityDate | 1974-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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