http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1091249-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c4cb9b5558ad97d3acc0db1113f7727 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215 |
| filingDate | 1976-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71f1ba788c4c594e857646a5d5baf651 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b2a8feed773f7083d5d187b3bb3ffdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84cd7d661fe8cb8a6ad7aa2d5bd84451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26fbabafb38218691aa59848d63b12db |
| publicationDate | 1980-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1091249-A |
| titleOfInvention | Process for the preparation of novel n-acyl- glutamines and compositions produced therefrom |
| abstract | PRECISION OF DISCLOSURE The subject of the present invention is a method of preparation of N-acylated glutamines of general formula I: I in which A is a hexagonal cyclic radical selected from the group consisting of cyclohexyl and phenyl. B is a hexagonal cyclic radical chosen from the group consisting of cyclohexyl, cyclohexenyl, cyclohexa-dienyl, phenyl and phenyl substituted by one or more halo genes, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, lower alkoxy, methylene dioxy, (lower alkyl) thio, lower alkenyl oxy or lower alkyl. R is hydrogen or a lower alkyl radical, and R1 is hydrogen, a monovalent cation derived a therapeutically compatible base, mineral or organic, lower alkyl or alkyl substituted by one or more hydroxyl groups or one or more amino groups; as well as obtaining the salts of the compounds of general formula I, for which R1 is hydrogen or a lower alkyl radical unsubstituted or substituted, with a mineral or organic acid preferably therapeutically compatible; as well as obtaining tion of the optically active forms of the compounds of formula general I either that glutamine is in racemic form or in optically active form, that is, the acetic chain has an asymmetric carbon atom when R is a radi-cal lower alkyl, i.e. again when A and / or B are non-aromatic cycles. The compounds of general formula I are obtained by condensation of a substituted acetic acid with glutamine or one of its alkyl esters. Compounds of general formula I have anti-inflammatory properties interesting and are suitable for use as a pharmaceutical positions as anti-rheumatic drugs. They are practically devoid of ulcerogenic effects at doses used in therapy. |
| priorityDate | 1975-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.