| abstract |
ABSTRACT Pharmacological compounds of the formula (I): (I) stereoisomers and pharmaceutically acceptable salts thereof wherein; X is CO, protected CO, CROH in which R is hydrogen or C1-4 alkyl and in which the OH moiety may be protected; Y is CH2CH2; Z is CO or CH2; n is 1 to 7; m is 1, 2 or 3; R1 is hydrogen, CH2OH, CH2OH in which the OH moiety is protected, CO2 W wherein W is hydrogen or C1- 4 alkyl; R2 is hydrogen, C1-4 alkyl, or taken together with R3 and the carbon atom to which it is attached represents a carbonyl group; R3 is hydrogen, hydroxy or protected hydroxy; R4 is hydrogen, or C1-9 alkyl. Methods for preparing the compounds are also described The compounds possess anti-gastric secretion activity cardiovascular activity, e.g. anti-hypertensive activity, platelet aggregation inhibition activity, respiratory tract activity, e.g. bronchodilator activity and antifertility and smooth muscle activity. |