http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1076573-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce010dfc8c8ee1224db9be853afeb081 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 |
| filingDate | 1977-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0a06ae771623bf84d90ab35d9cb0c0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f2aa442e491d0c81ce79960f1b0d685 |
| publicationDate | 1980-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1076573-A |
| titleOfInvention | Process for the production of 4-chloro-5-alkoxycarbonyl-2-methoxypyrimidine and its use in the preparation of 6-ethoxy-carbonyl-8-ethyl-2-methoxy-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidine |
| abstract | A B S T R A C T Process for the preparation of a 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine of the formula: in which R1 is a lower alkyl radical with 1 to 4 carbon atoms, which comprises the following stages: A) condensation of a salt of O-methylisourea and an inorganic or organic acid, with an alkyl alkoxy-methylenemalonate in an aqueous medium and in the presence of an excess of an alkali metal hydroxide. to form the corresponding salt. of the 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and neutralisation of the said salt by the addition of an inorganic or organic acid, in order to liberate this 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and B) bringing the latter compound, suspended in dimethylformamide, into contact with thionyl chloride, at room temperature, in order to form the corresponding 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine: Application to the preparation of 6-ethoxycarbonyl-8-ethyl-2-methoxy-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine. |
| priorityDate | 1976-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.